476468-68-5

Upstream product

• 75330-75-5 lovastatin 
• 100-46-9 benzylamine 
• 77550-67-5 ammonium mevinolinic acid 

Downstream Products

• 476305-25-6 N-benzyl-7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutanoyl]oxy]-1(S)-naphthyl]-3(R),5(R)-bis[(tert-butyldimethylsilyl)oxy]heptanoic acid amide 
• 939809-58-2 bis(TMS)-lovastatin-benzylamide 

Relevant academic research and scientific papers

Process for preparing simvastatin and intermediates thereof

Novel processes for the preparation of simvastatin and intermediates of such processes. Preferred embodiments include the preparation of lovastatin amides, protected lovastatin amide derivatives, simvastatin dihydroxy acid amide derivatives, alkali salts, simvastatin dihydroxy acids, simvastatin ammonium salts, and simvastatin.

Process for lactonization to produce simvastatin

There is disclosed a process for the manufacture of simvastatin of Formula I which comprises heating a compound, namely acid or ammonium salt of compound of Formula II, where Z is H or NH4 in an organic solvent at a temperature of 130-140° C. NameResidenceCitizenshipRamesh403, Janapriya Pramila EnclaveIndiaDandalaUma Nagar, Kundanbagh, BegumpetHyderabad - 500 016 (India)Sonny505, Vishal Towers, A BlockIndiaSebastianA.S. Raju Nagar, Kukatpally,Hyderabad - 500 072 (India)Sanapureddy4/134, Pakeerpalli,IndiaJagan MohanSankarapuram (post)ReddyCuddapah - 516 002 (India)MeenakshisunderamD-1, Hidden Treasure ApartmentsIndiaSivakumaranNear Ayyappa Swami Temple LaneSomajiguda, Hyderabad - 500 082(India)