476623-17-3

Upstream product

• 289503-26-0 N-tosyl-6-bromo-3-indolylboronic acid 
• 489431-66-5 2,5-dibromo-3-methoxypyrazine 
• 5900-13-0 5-bromo-3-methoxypyrazin-2-amine 
• 52415-29-9 6-bromo-1H-indole 
• 98-59-9 p-toluenesulfonyl chloride 
• 189265-99-4 6-bromo-1-(4-methylphenylsulfonyl)-1H-indole 
• 476622-89-6 5-bromo-2-iodo-3-methoxypyrazine 

Downstream Products

• 476622-84-1 7-Benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole 
• 756893-88-6 (1R,8R,10R,11R)-3-{5-[6-Bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-10-(tert-butyl-dimethyl-silanyloxy)-8-methoxy-11-methyl-5-(2-trimethylsilanyl-ethoxymethyl)-5-aza-tricyclo[6.3.1.0^2,6]dodeca-2⁽⁶⁾,3-dien-7-one 
• 852380-97-3 (1S,8S,11S)-3-{5-[6-Bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-8-methoxy-11-methyl-5-(2-trimethylsilanyl-ethoxymethyl)-5-aza-tricyclo[6.3.1.0^2,6]dodeca-2⁽⁶⁾,3-diene-7,10-dione 
• 476623-27-5 3-{7-benzyloxy-3-[5-(6-bromo-1H-indol-3-yl)-6-methoxy-pyrazin-2-yl]-1H-indol-4-yl}-1-nitro-butan-2-one 
• 476623-24-2 2-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-propionaldehyde 
• 476623-18-4 2-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-propionic acid 
• 476623-34-4 3-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-1-diazo-butan-2-one 
• 476623-19-5 3-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-1-bromo-butan-2-one 
• 476623-26-4 3-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-1-nitro-butan-2-one 
• 476623-35-5 1-amino-3-[7-benzyloxy-3-{5-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-4-yl]-butan-2-one 

Relevant academic research and scientific papers

The formal total synthesis of dragmacidin B, trans-dragmacidin C, and cis- and trans-dihydrohamacanthins A

A facile formal total synthesis of dragmacidin B, trans-dragmacidin C, and cis- and trans-dihydrohamacanthins A is presented. Our approach to these bis(indole) alkaloids involves a one-pot, four-step cross-coupling/deprotection sequence where complete hal

The first total synthesis of dragmacidin D

The first total synthesis of the biologically significant bis-indole alkaloid dragmacidin D (5) has been achieved. Thermal and electronic modulation provides the key for a series of palladium-catalyzed Suzuki cross-coupling reactions that furnished the core structure of the complex guanidine- and aminoimidazole-containing dragmacidins. Following this crucial sequence, a succession of meticulously controlled final events was developed leading to the completion of the natural product.

Preparing functional bis(indole) pyrazine by stepwise cross-coupling reactions: An efficient method to construct the skeleton of dragmacidin D

A direct approach for selective construction of properly substituted bis(indole) pyrazine, the skeleton of a marine alkaloid dragmacidin D, has been developed. The key steps involved the regioselective introduction of two indole units, using the palladium