477-83-8

Basic information

• Product Name: DAMNACANTHOL
• Synonyms: DAMNACANTHOL;3-Hydroxy-2-hydroxymethyl-1-methoxyanthracene-9,10-dione
• CAS NO: 477-83-8
• Molecular Formula: C₁₆H₁₂O₅
• Molecular Weight: 284.26
• Mol File: 477-83-8.mol

Chemical Properties

• Boiling Point: 527.5°Cat760mmHg
• Flash Point: 202°C
• Appearance: /
• Density: 1.455g/cm³
• Vapor Pressure: 9.55E-12mmHg at 25°C
• Refractive Index: 1.678
• CAS DataBase Reference: DAMNACANTHOL(CAS DataBase Reference)
• NIST Chemistry Reference: DAMNACANTHOL(477-83-8)
• EPA Substance Registry System: DAMNACANTHOL(477-83-8)

Safety Data

• Hazardous Substances Data: 477-83-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
DAMNACANTHOL is used as an anti-inflammatory agent for its potential to alleviate inflammatory conditions due to its inherent anti-inflammatory properties.
Used in Oncology:
DAMNACANTHOL is used as an anticancer agent for its ability to inhibit the growth of cancer cells, making it a candidate for the development of new cancer treatments.
Used in Antiviral Medications:
DAMNACANTHOL is used as an antiviral agent for its demonstrated activity against certain viruses, indicating its potential in developing treatments for viral infections.

InChI:InChI=1/C16H12O5/c1-21-16-11(7-17)12(18)6-10-13(16)15(20)9-5-3-2-4-8(9)14(10)19/h2-6,17-18H,7H2,1H3

Upstream product

• 63965-56-0 3-acetoxy-2-acetoxymethyl-1-methoxy-anthraquinone 
• 477-84-9 damnacanthal 
• 95316-44-2 3-acetoxy-2-acetoxymethyl-1-hydroxy-anthraquinone 
• 63965-55-9 1-methoxy-3-acetoxy-2-bromomethyl-1-methoxyathraquinone 
• 478-08-0 1,3-dihydroxy-2-hydroxymethyl-9,10-anthraquinone 

Downstream Products

• 61434-48-8 lucidin dimethyl ether 

Relevant articles and documents

Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II

In a series of searches for DNA topoisomerase II inhibitors from naturally occurring compounds, a wood extract of Neonauclea calycina MERR. (Rubiaceae) showed a moderate effect in vitro. Purification of the extract resulted in the isolation of seven known anthraquinones. The structures were characterized as damnacanthal, rubindin 1-methyl ether, nordamnacanthal, morindone, damnacanthol, lucidin 3-O-primeveroside and morindone 6-O- primeveroside by spectral analysis, respectively. Damnacanthal and morindone showed an intensive inhibitory effect against topoisomerase II (IC50: 20 μg/ml and 21 μg/ml).

New anthraquinone glycosides from the roots of Morinda citrifolia

Six new anthraquinone glycosides: digiferruginol-1-methylether-11-O-β-gentiobioside (1); digiferruginol-11-O-β-primeveroside (2); damnacanthol-11-O-β-primeveroside (3); 1-methoxy-2-primeverosyloxymethyl-anthraquinone-3-olate (4); 1-hydroxy-2-primeverosylo