477198-72-4

Upstream product

• 477198-54-2 diethyl 2-[(2S)-2-(tert-butyldimethylsilyloxy)-2-(5,9-dihydro-6,8-dioxabenzocyclohepten-7-yl)-ethyl]-malonate 
• 477198-51-9 diethyl (2S,5S)-2-[2-(tert-butyldimethylsilyloxy)-5-(2,6-dimethylphenoxycarbonyloxy)-6-(4-methoxyphenylmethoxy)-hex-3-enyl]malonate 
• 477198-55-3 diethyl (2S)-2-[2-(tert-butyldimethylsilyloxy)-6-(4-methoxyphenylmethoxy)-5-oxo-hex-3-enyl]malonate 
• 477198-57-5 2-[(E)-(2S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-(4-methoxy-benzyloxy)-hex-3-enyl]-malonic acid diethyl ester 
• 477198-59-7 diethyl (2S,3S)-3-(tert-butyldimethylsilyloxy)-2-[3-(4-methoxyphenylmethoxy)-propenyl]-cyclobutane-1,1-dicarboxylate 
• 477198-64-4 (2S,3S)-{3-(tert-butyldimethylsilyloxy)-1-hydroxymethyl-2-[3-(4-methoxyphenylmethoxy)-propenyl]-cyclobutyl}-methanol 
• 477198-53-1 3-[(1S)-2-methanesulfoxy-1-tert-butyldimethylsilanyoxyl]ethyl-1,5-dihydro-3H-2,4-benzodioxepine 
• 477198-52-0 2-[2-(tert-butyl-dimethyl-silanyloxy)-3-oxo-propyl]-malonic acid diethyl ester 
• 173613-40-6 1-(4-methoxyphenylmethoxy)-3-(triphenylphosphanylidene)-propan-2-one 
• 42134-49-6 (3-trimethylsilyl-2-propynyl)triphenylphosphonium bromide 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 477198-71-3 (2R,3S,5R,8R)-5-(tert-butyldimethylsilyloxy)-8-(4-methoxyphenylmethoxymethyl)-2-[(2E)-5-trimethylsilylpent-2-en-4-ynyl]-oxocan-3-ol 

Downstream Products

• 77182-65-1 (+)-laurenyne 

Relevant academic research and scientific papers

Synthetic and Mechanistic Studies of the Retro-Claisen Rearrangement 4. An Application to the Total Synthesis of (+)-Laurenyne

(Matrix Presented) A novel asymmetric total synthesis of marine natural product (+)-Laurenyne has been achieved. The key elements of the strategy are the sequential metal ion-templated SN2′ cyclization affording a highly functionalized chiral vinyl cyclobutane and a retro-Claisen rearrangement for the construction of an eight-membered ring ether.