477202-13-4

Usage

Chemical Structure

It consists of a six-carbon chain with a methoxyphenyl group attached to the first carbon atom.

Odor

Characterized by a sweet, floral, and fruity scent.

Common Uses

Flavoring ingredient in food products.
Fragrance in perfumes and cosmetics.

Industrial Applications

Intermediate in the synthesis of pharmaceuticals.
Intermediate in the production of other organic compounds.

Safety Precautions

Should be handled with care due to its harmful effects if ingested, inhaled, or in contact with skin and eyes.

Upstream product

• 131558-77-5 4-(hexyn-1-yl)anisole 
• 62-53-3 aniline 
• 2393-23-9 4-methoxy-benzylamine 
• 110-62-3 pentanal 
• 71017-75-9 1-(4-methoxybenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt 
• 591-78-6 n-hexan-2-one 
• 1139705-25-1 4-methoxyphenyl 1H-imidazole-1-sulfonate 

Relevant academic research and scientific papers

C-H Alkylation of Aldehydes by Merging TBADT Hydrogen Atom Transfer with Nickel Catalysis

Catalyst controlled site-selective C-H functionalization is a challenging but powerful tool in organic synthesis. Polarity-matched and sterically controlled hydrogen atom transfer (HAT) provides an excellent opportunity for site-selective functionalization. As such, the dual Ni/photoredox system was successfully employed to generate acyl radicals from aldehydes via selective formyl C-H activation and subsequently cross-coupled to generate ketones, a ubiquitous structural motif present in the vast majority of natural and bioactive molecules. However, only a handful of examples that are constrained to the use of aryl halides are developed. Given the wide availability of amines, we developed a cross-coupling reaction via C-N bond cleavage using the economic nickel and TBADT catalyst for the first time. A range of alkyl and aryl aldehydes were cross-coupled with benzylic and allylic pyridinium salts to afford ketones with a broad spectrum of functional group tolerance. High regioselectivity toward formyl C-H bonds even in the presence of α-methylene carbonyl or α-amino/oxy methylene was obtained.

Palladium-catalyzed mono-α-arylation of acetone with aryl imidazolylsulfonates

Set the ace(tone): A palladium catalyst derived from the bidentate XantPhos ligand and Pd(OAc)2 has enabled broadly applicable mono-α-arylations of acetone to be performed with air- and moisture-stable aryl imidazolylsulfonates as most user-friendly electrophiles (see scheme). Copyright

Aquapalladium complex: A stable and convenient catalyst for the intermolecular hydroamination of alkynes

The intermolecular hydroamination of alkynes proceeds very smoothly in the presence of a catalytic amount of the aquapalladium complex [Pd(dppe)(H 2O)2](TfO)2. This reaction most probably proceeds through the formation of an equilibrium between the hydroxopalladium and the amidopalladium complexes, and subsequent aminopalladation of alkynes. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

Palladium-catalyzed intermolecular hydroamination of alkynes: A dramatic rate-enhancement effect of o-aminophenol

The hydroamination of alkynes using o-aminophenol proceeds in very high to good yields in the presence of Pd(NO3)2 catalyst. Remarkable rate enhancement with o-aminophenol is presumably due to the chelation effect of the ortho OH group to palladium. Copyright

2-[(substituted)-phenoxymethyl]quinolines

Compounds having the formula: STR1 are selective antagonists of leukotrienes of D4 and inhibitors of the syntheses of LTA4, B4, C4, D4, E4, and F4. These compounds are useful as