477515-22-3Relevant academic research and scientific papers
Synthesis of new 5-aryl tetrazoline from N-aceto hydrazide cyclic imides and study of biological activity
Al-Haidari, Akram S.,Al-Tamimi, Entesar O.
, p. 5647 - 5653 (2021/09/11)
The research resulted in the production of new tetrazoline derivatives. Firstly; the reaction of N-acetyl chloro cyclic imides with hydrazine hydrate to give compounds (1,2). Then, compounds (1,2) were reacted with different aromatic aldehydes to give Schiff bases (3-10). The compounds of N-( 2-chloro acetyl) cyclic imides were reacted with sodium azide to give N- (azido acetyl) cyclic imides (11,12). Finally, the reaction of the prepared Schiff bases compounds with azide compounds and cyclization to give 5-aryl tetrazoline on cyclic imides (13-20). The prepared compounds were characterized by FT-IR and some of them by 1H NMR, melting point, and were studied the effects of the preparing compounds on some strains of bacteria and fungi.
Synthesis, characterization, andcomputational studies on phthalic anhydride-based benzylidene-hydrazide derivatives as novel,potential anti-inflammatory agents
Kajal, Anu,Bala, Suman,Kamboj, Sunil,Saini, Vipin
, p. 2676 - 2689 (2014/05/06)
A series of phthalic anhydride-based substituted benzylidene-hydrazide derivatives (3a-i) was synthesized. The synthesized derivatives were authenticated by TLC, UV-visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vivo anti-inflammatory and analgesic activities by carrageenan-induced rat paw oedema and tail immersion methods, respectively, using diclofenac sodium as standard drug. The derivatives 3d, 3e, and 3h were found to be most active anti-inflammatory and analgesic agents among all the synthesized derivatives. The physico-chemical similarity of the derivatives with standard drugs was assessed by calculating various physicochemical properties using software programs. The percent similarity of synthesized derivatives was found to be good except 3i. The derivatives were subjected to QSAR by multilinear regression using Analyze it version 3.0 software and two statistically sound models were developed with R2 (0.933-0.960), Radj2 (0.595-0.762) and Q2 (0.999) with good F (2.76-4.84) values. Molecular docking studies were performed by MVD software (version 2012.5.0.0). The derivative 3h has emerged out as most potent anti-inflammatory agent with highest dock score, i.e., -93.64. Springer Science+Business Media 2013.
