477526-92-4

Upstream product

• 453509-71-2 (S)-2-((R)-2-Isocyano-4-methyl-pentanoylamino)-3-methyl-butyric acid methyl ester 
• 5338-45-4 N-formyl-D-leucine 
• 477523-80-1 (S)-2-{(R)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionyloxy)-3-tert-butoxycarbonylamino-pentanoylamino]-4-methyl-pentanoylamino}-3-methyl-butyric acid methyl ester 

Relevant academic research and scientific papers

Short synthesis of protease inhibitors via modified Passerini condensation of N-Boc-α-aminoaldehydes

Extension of the previously reported modification of Passerini multicomponent reaction (involving condensation with N-Boc-α-aminoaldehydes followed by a deprotection-transacylation step) to α-aminoacid derived carboxylic or isocyanide components, allowed the highly convergent and short synthesis of complex peptidomimetic structures, including known potent inhibitors of serine proteases.