477528-91-9Relevant academic research and scientific papers
Synthesis, molecular properties, anti-inflammatory and anticancer activities of novel 3-hydroxyflavone derivatives
Znati, Mansour,Bordes, Claire,Forquet, Valérian,Lantéri, Pierre,Ben Jannet, Hichem,Bouajila, Jalloul
, (2019)
A new series of 3-hydroxyflavones (1–46) were synthesized according to the Claisen-Schmidt followed by Algar-Flynn-Oyamada reactions (AFO) in one step. The synthesized flavonoids were characterized by 1H NMR, 13C NMR and DCI-HRMS. All the synthesized compounds were tested in vitro for their 15-lipoxygenase inhibitory and cytotoxic activity against the human cell lines HCT-116 (Human colon carcinoma), IGROV-1 and OVCAR-3 (human ovarian carcinoma). It has been found that the derivatives 25, 37 and 45 were the most actives against HCT-116 (IC50 = 8.0, 9.0 and 9.0 μM, respectively) and against IGROV-1 (IC50 = 2.4, 5.0 and 6.0 μM, respectively). The derivatives 14 and 21 exhibited the higher anti-inflammatory activity at 100 μM with PI values of 76.50 and 72.70%, respectively. Molecule description was performed with DFT calculations, the drug likeness and bioactivity scores. The results exhibted that some compounds are in linear correlation with Lipinski's rule of five showing good drug likeness and bioactivity score for drug targets.
Synthesis and characterization of Ru(II)-DMSO-Cl-chalcone complexes: DNA binding, nuclease, and topoisomerase II inhibitory activity
Gaur, Ruchi,Mishra, Lallan
scheme or table, p. 3059 - 3070 (2012/04/23)
The complexes of type cis-[Ru(S-DMSO)3(R-CO-CH-CH-R′)Cl] (R = 2-hydroxyphenyl for all, R′ = phenyl 1, naphthyl 2, anthracenyl 3, thiophene 4, 3-methyl thiophene 5) are synthesized and characterized using spectroscopic (IR, 1H and su
Synthesis of α-azido-2′-hydroxychalcones from chalcone dibromides with azide ion
Patonay, Tamas,Jekoe, Jozsef,Riman, Eva
, p. 2403 - 2415 (2007/10/03)
The reaction of the 2′-hydroxychalcone dibromides with azide ion was found to afford various products such as α-azido-2′-hydroxychalcones, flavones, aurones, isoxazoles or the parent chalcones depending on the substituent pattern of the substrate. Efficie
