477543-22-9

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 4760-34-3 N-methyl-1,2-phenylenediamine 
• 95-54-5 1,2-diamino-benzene 
• 77738-96-6 2-(3-bromo-phenyl)-1H-benzoimidazole 
• 74-88-4 methyl iodide 
• 585-76-2 m-bromobenzoic acid 

Downstream Products

• 1160829-71-9 [2-[3-(3-fluoro-4-morpholin-4-yl)-piperidin-1-yl]-phenyl]-1-methyl-1H-benzoimidazole 
• 1258281-53-6 ethyl 1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidine-4-carboxylate 
• 1612250-71-1 {1-[3-(1-methylbenzimidazol-2-yl)phenyl]piperidin-4-yl}-(4-methypiperazin-1-yl)methanone hydrobromide 

Relevant academic research and scientific papers

ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND

An organometallic compound represented by Formula 1: wherein, in Formula 1, groups and variables are the same as described in the specification.

Design, synthesis and evaluation of novel tetrahydrothieno[3,2-c]pyridine derivatives as potent smoothened antagonists

Hedgehog (Hh) signalling plays an important role in embryonic development and adult tissue homeostasis. Since activation of the Hh signalling pathway is implicated in several types of human cancers, inhibitors of this pathway could be promising anticancer

LUMINESCENT COMPOUNDS AND METHODS OF USING SAME

The invention provides compounds of the general formula (10). The cyclometallating ligand of compound (10) includes an N-donor heterocyclic ligand (2) where at least one X is nitrogen and which is directly bonded to a phenyl group. The phenyl group is ort

A scalable route to the SMO receptor antagonist SEN826: Benzimidazole synthesis via enhanced in situ formation of the bisulfite-aldehyde complex

A practical and scalable route to the SMO antagonist SEN826 1 is described herein, including the discussion of an alternative approach to the synthesis of the target molecule. The optimized route consists of five chemical steps. A new and efficient access to the key intermediate 6 via the bisulfite-aldehyde complex was developed, significantly enhancing the yields and reducing costs. As a result, a synthetic procedure for preparation of multihundred gram quantities of the final product has been developed.

HEDGEHOG PATHWAY ANTAGONISTS AND THERAPEUTIC APPLICATIONS THEREOF

Heterocyclic compounds that modulate the hedgehog signaling pathway, pharmaceutical composition thereof and their therapeutic applications.