477559-22-1Relevant articles and documents
A practical method for synthesis of stable phosphorus ylides in aqueous media
Islami,Yavari,Tikdari,Ebrahimi,Razee,Bijanzadeh
, p. 2244 - 2247 (2002)
A convenient one-pot synthesis of stable phosphorus ylides by the condensation of triphenylphosphine with dialkyl acetylenedicarboxylate and CH acids, such as penta-2,4-dione or diethyl propane-1,3-dioate, in the presence of β-cyclodextrin as a catalyst (to increase the solubility of the reactants in water) without using toxic organic solvents was proposed. This methodology is of interest due to the use of water as a solvent, thus minimizing such factors as the cost, operational hazards, and environmental pollution.
The reaction of phenylhydrazine with sterically congested stabilized phosphorus ylides in the presence of silica gel powder in solvent-free conditions: A novel synthesis of fully substituted pyrazole derivatives
Noshiranzadeh, Nader,Ramazani, Ali
scheme or table, p. 1109 - 1115 (2009/04/07)
Reactions of sterically congested stabilized phosphorus ylides with phenylhydrazine in the presence of silica gel powder in solvent-free conditions proceed smoothly at 100°C to afford dialkyl 2-(3,5-dimethyl-1-phenyl-1H- pyrazol-4-yl)-2-butenedioates in good yields. The structures of the products were deduced from their IR, 1H NMR, and 13C NMR spectra. The mass spectra of these compounds displayed molecular ion peaks at the appropriate z values. The 1H NMR (CDCl3) spectra of the compounds show the presence of two estereoisomers (E and Z) for each pyrazoles. The relative population of E and Z isomers were determined via their 1H NMR spectra The reaction is fairly stereoselective. Copyright Taylor & Francis Group, LLC.
