477576-97-9

Usage

General Description

1-Piperidineethanamine,4-fluoro-(9CI) is a compound with the chemical formula C8H14FN. It is a fluorinated derivative of the organic compound 1-piperidineethanamine, and is also known by its IUPAC name 4-fluoro-1-piperidineethanamine. This chemical is important in medicinal chemistry and pharmaceutical research, as it has potential applications in the development of new drugs and therapeutic treatments. The 4-fluoro substitution on the piperidine ring may have significant effects on the compound's biological activity and pharmacological properties, making it a valuable target for further study and exploration in drug discovery and development.

Upstream product

• 57395-89-8 4-fluoropiperidine hydrochloride 
• 477576-96-8 2-(4-fluoropiperidin-1-yl)acetonitrile 

Relevant academic research and scientific papers

AMIDO-SUBSTITUTED AZOLE COMPOUNDS

The present invention relates to amido-substituted azole compounds of general formula (I), in which X1, X2, R1, R2, R4, R5, R7 and R8 are as defined in the claims which are inhibitors of TNKS1 and/or TNKS2, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

PKM2 MODULATORS AND METHODS FOR THEIR USE

Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein

Aryl compounds with aminoalkyl substituents and their use

The present application relates to novel aryl compounds with aminoalkyl substituents, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.

5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to certain 5-aralkylsulfonyl-3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular met kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.