477712-02-0

Basic information

• Product Name: 5-(4-CHLOROPHENYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
• Synonyms: 5-(4-CHLOROPHENYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
• CAS NO: 477712-02-0
• Molecular Formula: C₁₆H₁₀ClFN₂O₂
• Molecular Weight: 316.71
• Mol File: 477712-02-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-CHLOROPHENYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-CHLOROPHENYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID(477712-02-0)
• EPA Substance Registry System: 5-(4-CHLOROPHENYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID(477712-02-0)

Safety Data

• Hazardous Substances Data: 477712-02-0(Hazardous Substances Data)

Upstream product

• 1220524-63-9 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 1220524-90-2 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid amide 

Relevant articles and documents

Synthesis and antimicrobial activities of novel 1,5-diaryl pyrazoles

Novel 1,5-diaryl pyrazole derivatives viz. 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamides (2a-e, 3, 3a-f), 2-(5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-yl)thiazoles (6a-c,7, 8, 9a-c, 10, 11) were synthesized by varying the active part (amide group) of pyrazole, characterized using IR, 1H NMR, mass spectral data and screened for their antibacterial activity against Escherichia coli (ATTC-25922), Staphylococcus aureus (ATTC-25923), Pseudomonas aeruginosa (ATTC-27853), Klebsiella pneumonia. Similarly all these compounds were screened for their antifungal activity against Aspergillus flavus (NCIM No. 524), Aspergillus fumigates (NCIM No. 902), Penicillium marneffei and Trichophyton mentagrophytes. Interestingly all the synthesized compounds exhibited good antibacterial (except 2a-c, 8, 9a) and antifungal activity (except 2a-c, 6a, 8, 9a).