477717-15-0Relevant academic research and scientific papers
On the introduction of a trifluoromethyl substituent in the epothilone setting: chemical issues related to ring forming olefin metathesis and earliest biological findings.
Rivkin, Alexey,Biswas, Kaustav,Chou, Ting-Chao,Danishefsky, Samuel J
, p. 4081 - 4084 (2002)
The disclosure herein describes the synthesis of 10,11-dehydro-13,14-desoxy-27-trifluoro-[17]epothilone B via a stereoselective ring-closing metathesis and provides early biological evaluation data pertinent to this compound. [reaction: see text]
