477727-56-3Relevant academic research and scientific papers
NOVEL TRICYCLIC AND HETEROTRICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THEREOF
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Page/Page column 41-42, (2008/12/06)
The present invention concerns novel tricyclic and heterotricyclic derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
Pyrimidines and uses thereof
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, (2008/06/13)
The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor-cells.
Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: Inhibitors of lysophosphatidic acid acyltransferase-β
Gong, Baoqing,Hong, Feng,Kohm, Cory,Jenkins, Scott,Tulinsky, John,Bhatt, Rama,De Vries, Peter,Singer, Jack W.,Klein, Peter
, p. 2303 - 2308 (2007/10/03)
2,4-Diamino-N4,6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-β (LPAAT-β). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in
Inhibitors of protein kinase for the treatment of disease
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, (2008/06/13)
The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.
