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2-Hydroxy-3-methyl-5-(1-pyrrolidinyl)-1,4-benzoquinone, also known as atovaquone, is a chemical compound belonging to the class of benzoquinones. It is a potent antiparasitic drug, primarily used for the treatment and prevention of Pneumocystis jirovecii pneumonia (PCP) in immunocompromised patients, such as those with HIV/AIDS or undergoing organ transplantation. Atovaquone works by inhibiting the mitochondrial electron transport chain in susceptible organisms, leading to their death. It is available in oral formulations and is often used in combination with other medications to enhance its efficacy. The chemical structure of atovaquone features a benzoquinone core with a hydroxyl group at the 2-position, a methyl group at the 3-position, and a pyrrolidinyl group at the 5-position, which contributes to its unique pharmacological properties.

4778-27-2

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4778-27-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4778-27-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,7 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4778-27:
(6*4)+(5*7)+(4*7)+(3*8)+(2*2)+(1*7)=122
122 % 10 = 2
So 4778-27-2 is a valid CAS Registry Number.

4778-27-2Downstream Products

4778-27-2Relevant academic research and scientific papers

Amine Addition to Unsymmetrical Benzoquinones

Luly, Jay R.,Rapoport, Henry

, p. 2745 - 2752 (2007/10/02)

New routes to 2-methoxy-3-methyl-1,4-benzoquinone and 4-methoxy-3-methyl-1,2-benzoquinone have been developed.Both quinones undergo highly regioselective oxidative amination with pyrrolidine and copper acetate, yielding aminoquinones related to the mitomy

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