4778-79-4

Upstream product

• 59479-66-2 2-(3-Hydroxyphenyl)-1H-isoindole-1,3-(2H)dione 
• 2417-73-4 methyl 2-bromomethylbenzoate 
• 591-27-5 m-Hydroxyaniline 
• 89-71-4 2-Methyl-benzoic acid methyl ester 

Relevant academic research and scientific papers

One-pot method to construct isoindolinones and its application to the synthesis of DWP205109 and intermediate of Lenalidomide

Herein a practical and efficient system for concise synthesis of isoindolinones is described by using substituted methyl 2-(halomethyl)benzoates and substituted amines. Structurally various methyl 2-(halomethyl)benzoates and amines were transformed into isoindolinones 80–99% yield and purity in catalyst-free and solvent-free conditions. The method has a wide substrate scope. The synthetic utility of the one-pot reaction was demonstrated by the concise syntheses of Lenalidomide intermediate and DWP205190.

Synthetic method of isoindolinone compound

The invention belongs to the field of chemical synthesis, and particularly relates to a synthesis method of an isoindolinone compound. The isoindolinone compound is represented by formula (I), in which R, R1 and R2 are used for representing any substituent groups. According to the synthetic method of the isoindolinone compound, a new process for solvent-free synthesis of the isoindolinone compoundis developed; no solvent is used, so that the separation and purification process of the product is easier to carry out, the green production of fine chemicals is effectively realized, the operationis simple, the reaction time is obviously shortened, the production efficiency of the product is increased, the quality and yield are improved, the yield can reach 81%-99%, and the purity can reach 96%-99%.

Some 7-Substituted 4-(Trifluoromethyl)coumarins

Preparation and spectral properties are given for 13 substituted 4-(trifluoromethyl)coumarins (7-hydroxy, 7,8-dihydroxy, 6-ethyl-7-hydroxy, 6-benzyl-7-hydroxy, 7-methoxy, 7-methyl, 7-amino, 7-(ethylamino), 7-(benzylamino), 7-anilino, 7-, 7-, and 2(1H)-isoindolyl).Three 7-(acylamido)-4-(trifluoromethyl)coumarins (acetyl, benzoyl, and bromoacetyl) were also prepared as well as two new phenol precursors, 3-phenol and 2-(3-hydroxyphenyl)-1H-isoindole.