4778-80-7

Usage

Bicyclic heterocyclic compound

A compound with a ring structure consisting of two cycles or rings, with at least one ring containing a heteroatom (an atom other than carbon) in the structure.

Derivative of isoindoline

A compound that is structurally related to isoindoline, a bicyclic heterocyclic compound with potential pharmaceutical applications.

Hydroxyphenyl group

A functional group consisting of a hydroxyl (-OH) group attached to a phenyl ring (a six-carbon ring with alternating single and double bonds), known for its antioxidant properties.

Potential pharmaceutical applications

The compound may have potential use in the development of new drugs or in research related to neurological and psychiatric disorders due to the presence of the isoindoline ring and hydroxyphenyl group in its structure.

Common in various pharmaceuticals

The isoindoline ring is a common structural component in a variety of pharmaceuticals, including some antipsychotic and antidepressant medications.

Upstream product

• 588-53-4 4-benzylidenamino-phenol 
• 123-30-8 4-amino-phenol 
• 119-67-5 o-carboxybenzaldehyde 
• 7154-85-0 2-(4-hydroxyphenyl)-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 65307-08-6 N-[4-(2,3-epoxypropoxy)phenyl]-1-oxo-isoindoline 
• 680576-45-8 N-[4-(3-chloropropoxy)phenyl]-1-oxo-isoindoline 

Relevant academic research and scientific papers

Highly efficient synthesis of N-substituted isoindolinones and phthalazinones using Pt nanowires as catalysts

A series of N-substituted isoindolinones have been successfully synthesized through the reductive C-N coupling and intramolecular amidation of 2-carboxybenzaldehyde and amines. This one-pot synthesis gives excellent yields using ultrathin Pt nanowires as catalysts under 1 bar of hydrogen. These unsupported catalysts can also be used for the synthesis of phthalazinones in high yield when hydrazine or phenyl hydrazine is used instead of amines.

Synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethoxy-1-oxo-isoindoline)- substituted phenoxypropanolamines and their β1-, β2-adrenergic receptor binding studies

Phenoxypropanolamines with 1-oxo-isoindoline (12-16) and 5,6-dimethoxy-1-oxo-isoindoline groups (17-20) at the para position were synthesized. β1, β2-Adrenergic receptor binding affinities for the synthesized compounds were tested and compared with propranolol and atenolol. It was found that the incorporation of para-amidic functionality within the 1-oxo-isoindoline ring and 5,6-dimethoxy-1-oxo- isoindoline ring system led to a high degree of cardioselectivity in the phenoxypropanolamines. Two of the compounds 12 and 20 possessed β1-adrenergic receptor affinity comparable with that of atenolol and both showed a better cardioselectivity than atenolol. Both 12 and 20 are undergoing further pharmacological evaluation.