477886-49-0Relevant academic research and scientific papers
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1 H -imidazo[2,1- a ]isoindol-5(9b H)-one (ML375)
Gentry, Patrick R.,Kokubo, Masaya,Bridges, Thomas M.,Kett, Nathan R.,Harp, Joel M.,Cho, Hyekyung P.,Smith, Emery,Chase, Peter,Hodder, Peter S.,Niswender, Colleen M.,Daniels, J. Scott,Conn, P. Jeffrey,Wood, Michael R.,Lindsley, Craig W.
, p. 9351 - 9355 (2014/01/06)
A functional high throughput screen and subsequent multidimensional, iterative parallel synthesis effort identified the first muscarinic acetylcholine receptor (mAChR) negative allosteric modulator (NAM) selective for the M5 subtype. ML375 is a
POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS
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Page/Page column 47, (2010/02/12)
Compounds of formula (I), and their use as in the treatment of infections involving viruses of the Pneumovirinae sub-family (RSV) are disclosed. In the formula ring (A) may be phenyl, pyridyl etc., (B-C) may be CH2-CH2etc., (R1) may be phenyl and substituted forms thereof, (R2) may be assorted substituents.
