47791-90-2

Upstream product

• 15357-95-6 7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 50-00-0 formaldehyd 
• 1263210-07-6 C₃₁H₃₀BrNO₃ 
• 35596-93-1 (R)-1-(4-benzyloxybenzyl)-2-methyl-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline 
• 1263210-02-1 (R)-1-(3-bromo-4-benzyloxybenzyl)-2-formyl-6-methoxy-7-benzyloxy-l,2,3,4-tetrahydroiso-quinoline 

Downstream Products

• 1438250-54-4 (R)-7-(benzyloxy)-1-[(4-(benzyloxy)-3-[(R)-1-(4-isopropoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy]benzyl)]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera

Bisbenzylisoquinoline alkaloid, nelumboferine which was recently isolated from the embryo of Nelumbo nucifera, and stereoisomers of neferine, which is a major alkaloid of the embryo of N. nucifera, were stereoselectively synthesized. Pharmacological activity of nelumboferine, stereoisomers of neferine, liensinine, isoliensinine, and O-methylneferine were evaluated.

Formal synthesis of the bisbenzylisoquinoline alkaloid berbamunine by asymmetric substitution of chiral organolithium compounds

Asymmetric alkylation of enantiomeric tetrahydroisoquinolyl oxazolines was achieved with 96-97% diastereoselectivity. Removal of the oxazoline chiral auxiliary and further transformations provide a straightforward synthesis of the two synthetic intermediates that were previously synthesized by resolution, and which comprise a formal synthesis of berbamunine by Ullman coupling. ARKAT-USA, Inc.