477961-03-8

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-[bis(4-ethenylphenyl)hydroxymethyl]-, 1,1-dimethylethyl ester, (2S)-
• CAS NO: 477961-03-8
• Molecular Formula: C26H31NO3
• Molecular Weight: 405.537
• Mol File: 477961-03-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-[bis(4-ethenylphenyl)hydroxymethyl]-, 1,1-dimethylethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-[bis(4-ethenylphenyl)hydroxymethyl]-, 1,1-dimethylethyl ester, (2S)-(477961-03-8)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-[bis(4-ethenylphenyl)hydroxymethyl]-, 1,1-dimethylethyl ester, (2S)-(477961-03-8)

Safety Data

• Hazardous Substances Data: 477961-03-8(Hazardous Substances Data)

Upstream product

• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 18120-63-3 (4-vinylphenyl)magnesium bromide 

Downstream Products

• 477961-09-4 1-[2-[hydroxy[bis(4-vinylphenyl)]methyl]pyrrolidin-1-yl]-1-propanone 
• 157020-06-9 (S)-(-)-α,α-di(4-vinylphenyl)-2-pyrrolidinemethanol 

Relevant articles and documents

POLYMER SUPPORTED FLUORINATED ORGANOCATALYST

Polymer supported fluorinated compound of formula I, wherein the meaning for each R1 is as disclosed in the description. These compounds are useful as catalysts, particularly in Michael addition reactions under continuous flow.

Comparison of enantioselective reductions using bead and monolith 'disk' polymer formulations of CBS catalysts

Two polymer-supported versions of the Corey, Bakshi, and Shibata (CBS) catalyst were prepared and examined. Polymeric beads, with the auxiliary bound in pendant and crosslinked fashion, were prepared utilizing an improved procedure based upon earlier work. Optimization of a procedure for ketone reduction gives results that match those in solution. Attempted reuse gave mixed results. For comparison purposes, CBS functionalized monoliths were formed and tested but performed poorly.

Comparison of solid-phase and solution-phase chiral auxiliaries in the alkylation/iodolactonization sequence to γ-butyrolactones

Five prolinol-based chiral auxilaries have been compared for the stereoselective synthesis of γ-butyrolactones via the sequence of N-acylation, Cα-allylation, and iodolactonization under both solution-phase and solid-phase conditions. Comparisons of stereoselectivity of both the Cα-allylation and iodolactonization processes indicate that incorporation of a non-C2-symmetric auxiliary as a polymer cross-link gives results superior to those obtained either in solution or with other non-C2-symmetric auxiliaries and comparable to those observed using a polymer-supported pseudo-C2-symmetric auxiliary.