478012-24-7Relevant academic research and scientific papers
Design, synthesis and biological activity of carbohydrate-containing peptidomimetics as new ligands for the human tachykinin NK-2 receptor
Capozzi, Giuseppe,Giannini, Sabrina,Menichetti, Stefano,Nativi, Cristina,Giolitti, Alessandro,Patacchini, Riccardo,Perrotta, Enzo,Altamura, Maria,Alberto Maggi, Carlo
, p. 2263 - 2266 (2007/10/03)
Enantiopure cycloadducts between glycals and alkyl or aryl heterodienes were selected as small, rigid, nonpeptide molecules able to superimpose to the structure of the cyclopeptide tachykinin NK-2 antagonist 1. The presence of three aromatic groups in the pyranose ring resulted essential for NK-2 affinity, while an increase in activity was shown by the corresponding sulfoxides.
