478012-72-5

Basic information

• Product Name: 4-bromo-benzoic acid 2,2-dimethyl-4H-benzo[1,3]dioxin-5-ylmethyl ester
• Synonyms: 4-bromo-benzoic acid 2,2-dimethyl-4H-benzo[1,3]dioxin-5-ylmethyl ester
• CAS NO: 478012-72-5
• Molecular Weight: 377.235
• Mol File: 478012-72-5.mol

Chemical Properties

• CAS DataBase Reference: 4-bromo-benzoic acid 2,2-dimethyl-4H-benzo[1,3]dioxin-5-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-benzoic acid 2,2-dimethyl-4H-benzo[1,3]dioxin-5-ylmethyl ester(478012-72-5)
• EPA Substance Registry System: 4-bromo-benzoic acid 2,2-dimethyl-4H-benzo[1,3]dioxin-5-ylmethyl ester(478012-72-5)

Safety Data

• Hazardous Substances Data: 478012-72-5(Hazardous Substances Data)

Upstream product

• 586-75-4 4-chlorobenzoyl chloride 
• 112429-70-6 (2,2-dimethyl-4H-benzo[d][1,3]dioxin-5-yl)methanol 

Downstream Products

• 478012-71-4 4-bromo-benzoic acid 3-(2-methyl-allyloxy)-2-[4-methyl-3,3-bis-(3-methyl-but-2-enyl)-2,6-dioxo-cyclohexanecarbonyl]-benzyl ester 
• 857651-90-2 4-bromo-benzoic acid 2-[2-methoxy-4-methyl-3,3-bis-(3-methyl-but-2-enyl)-6-oxo-cyclohex-1-enecarbonyl]-3-(2-methyl-allyloxy)-benzyl ester 
• 478012-63-4 4-Bromo-benzoic acid 2-{methoxy-[4-methyl-3,3-bis-(3-methyl-but-2-enyl)-2,6-dioxo-cyclohex-(Z)-ylidene]-methyl}-3-(2-methyl-allyloxy)-benzyl ester 
• 478014-69-6 4-bromo-benzoic acid 2-[2-methoxy-4-methyl-5,5-bis-(3-methyl-but-2-enyl)-6-oxo-cyclohex-1-enecarbonyl]-3-(2-methyl-allyloxy)-benzyl ester 
• 478012-70-3 4-bromo-benzoic acid 2-[3-allyl-4-methyl-3-(3-methyl-but-2-enyl)-2,6-dioxo-cyclohexanecarbonyl]-3-(2-methyl-allyloxy)-benzyl ester 
• 478012-76-9 4-bromo-benzoic acid 2-[methoxy-(4-methyl-2,6-dioxo-cyclohexylidene)-methyl]-3-(2-methyl-allyloxy)-benzyl ester 
• 478012-59-8 4-bromo-benzoic acid 3-(2-methyl-allyloxy)-2-(4-methyl-2,6-dioxo-cyclohexanecarbonyl)-benzyl ester 
• 857652-20-1 4-bromo-benzoic acid 2-(cyano-hydroxy-methyl)-3-(2-methyl-allyloxy)-benzyl ester 
• 478012-54-3 4-bromo-benzoic acid 2-cyanocarbonyl-3-(2-methyl-allyloxy)-benzyl ester 
• 857652-19-8 4-bromo-benzoic acid 2-formyl-3-(2-methyl-allyloxy)-benzyl ester 
• 478012-53-2 4-bromo-benzoic acid 2-formyl-3-hydroxy-benzyl ester 
• 857651-98-0 4-bromo-benzoic acid 2-[2-methoxy-5-(2-methyl-allyl)-5-(3-methyl-but-2-enyl)-6-oxo-cyclohex-1-enecarbonyl]-3-(2-methyl-allyloxy)-benzyl ester 

Relevant articles and documents

The total synthesis of coleophomones B and C

Pushing the frontiers of olefin metathesis: As the coleophomones B (1) and C (2) differ only in the configuration of the Δ16,17 double bond, ring-closing metathesis was chosen as the method for their construction following an initially converge

The total synthesis of coleophomones B, C, and D

Members of the coleophomone family of natural products all possess several intriguing and challenging architectural features, as well as exhibit unusual biological activity. They, therefore, constitute attractive targets for synthesis. In this Article, we describe the total synthesis of coleophomones B (2), C (3), and D (4). The highly strained and congested 11-membered macrocycle of coleophomones B (2) and C (3) was constructed using an impressive olefin metathesis reaction. Furthermore, both of the requisite geometric isomers of the Δ within the macrocycle could be accessed from a common precursor, facilitating a divergence that lent the coleophomone B (2)/C (3) synthesis an unusually high degree of efficiency. The synthesis of coleophomone D (4) confirmed that it exists as a dynamic mixture of isomeric forms with a different aromatic substitution pattern from the other family members.