478078-66-9

Upstream product

• 621-40-9 (3-methylphenyl)thiourea 
• 1694-29-7 3-chloropentane-2,4-dione 
• 123-54-6 acetylacetone 

Downstream Products

• 1257438-73-5 1-[2-(3-methylphenylamino)-4-methyl-thiazole-5-yl]-3-(4-chlorophenyl)-propen-1-one 
• 1257438-75-7 1-[2-(3-methylphenylamino)-4-methyl-thiazole-5-yl]-3-(2-chlorophenyl)-propen-1-one 
• 1257438-74-6 1-[2-(3-methylphenylamino)-4-methyl-thiazole-5-yl]-3-(3,4,5-trimethoxyphenyl)-propen-1-one 
• 1257438-72-4 1-[2-(3-methylphenylamino)-4-methyl-thiazole-5-yl]-3-phenyl-propen-1-one 
• 1257438-71-3 1-[2-(3-methylphenylamino)-4-methyl-thiazole-5-yl]-3-(3-methoxyphenyl)-propen-1-one 
• 1333391-28-8 {4-[2-(m-tolyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-N-phenylamine 
• 1333391-29-9 {4-[2-(m-tolyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-m-tolylamine 
• 1333391-24-4 {4-[2-(m-tolyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-(3-chlorophenyl)amine 
• 1333391-46-0 {4-[2-(m-tolyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-(3-methoxyphenyl)amine 
• 1333391-54-0 {4-[2-(m-tolyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-(4-fluorophenyl)amine 
• 1333391-58-4 3-dimethylamino-1-[4-methyl-2-(methyl(m-tolyl)amino)thiazol-5-yl]propenone 

Relevant academic research and scientific papers

Thiazole fused thiosemicarbazones: Microwave-assisted synthesis, biological evaluation and molecular docking study

In the present study, series of novel compounds (E)-2-(1-(4-methyl-2-(substituted-phenylamino)thiazol-5-yl)ethylidene)hydrazinecarbothio-amide (5a-j) and (E)-N-cyclohexyl-2-(1-(4-methyl-2-(substituted-phenylamino)thiazol-5-yl)ethylidene)hydrazinecarbothio

Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro

A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by 1H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549. Thiazolyl-pyrimidines were synthesized by the general pyrimidine condensation of Bredereck and their in-vitro anticancer activities were evaluated. Copyright

Synthesis and anticancer evaluation of thiazolyl-chalcones

Thirty-seven (E)-1-(4-methyl-2-arylaminothiazol-5-yl)-3-arylprop-2-en-1- ones were synthesized via Claisen-Schmidt condensation of 1-(4-methyl-2- (arylamino)thiazol-5-yl)ethanone with the corresponding arylaldehydes. All these thiazolyl-chalcones were cha