478259-37-9Relevant academic research and scientific papers
The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38α MAP kinase
Down, Kenneth,Bamborough, Paul,Alder, Catherine,Campbell, Amanda,Christopher, John A.,Gerelle, Maria,Ludbrook, Steve,Mallett, Dave,Mellor, Geoff,Miller, David D.,Pearson, Rosannah,Ray, Keith,Solanke, Yemisi,Somers, Don
scheme or table, p. 3936 - 3940 (2010/08/19)
A novel pyrrole-2-carboxamide series of p38α inhibitors, discovered through the application of virtual screening, is presented. Following evaluation of activity, selectivity and developability properties of commercially available analogues, a synthesis program enabled rapid assessment of the series' suitability for further lead optimisation studies.
