478288-94-7

Basic information

• Product Name: (S)-BEL
• Synonyms: (S)-BEL;(S)-BROMOENOL LACTONE;6E-(BROMOMETHYLENE)TETRAHYDRO-3-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE;(3S,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
• CAS NO: 478288-94-7
• Molecular Formula: C16H13BrO2
• Molecular Weight: 317.18
• Mol File: 478288-94-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 467.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.538±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (S)-BEL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-BEL(478288-94-7)
• EPA Substance Registry System: (S)-BEL(478288-94-7)

Safety Data

• Hazardous Substances Data: 478288-94-7(Hazardous Substances Data)

Usage

Description

(S)-BEL, also known as S-adenosylmethionine decarboxylase inhibitor, is a chemical compound that plays a significant role in the study of polyamine metabolism in various biological processes. It functions as an inhibitor of the enzyme S-adenosylmethionine decarboxylase, which is involved in the synthesis of polyamines, essential molecules for cell growth and proliferation. By inhibiting this enzyme, (S)-BEL can influence polyamine levels and subsequently affect cell behavior, making it a valuable tool for understanding the functions of polyamines in health and disease.

Uses

Used in Research Applications:
(S)-BEL is used as a research tool for studying the role of polyamine metabolism in various biological processes. Its ability to inhibit the enzyme S-adenosylmethionine decarboxylase allows researchers to investigate the effects of altered polyamine levels on cell behavior and function.
Used in Pharmaceutical Applications:
(S)-BEL is used as a potential therapeutic target for cancer treatment. The dysregulation of polyamine metabolism has been implicated in cancer development and progression, making (S)-BEL a promising compound for the development of new cancer treatments. By targeting the enzyme S-adenosylmethionine decarboxylase, (S)-BEL may help to modulate polyamine levels and potentially inhibit cancer cell growth and proliferation.
Used in Drug Development:
(S)-BEL is used in the development of novel drug delivery systems to enhance its applications and efficacy against cancer cells. Researchers are exploring various organic and metallic nanoparticles as carriers for (S)-BEL delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes in cancer treatment.