478296-30-9Relevant academic research and scientific papers
Synthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes
Norsikian, Stéphanie,Beretta, Margaux,Cannillo, Alexandre,Martin, Amélie,Retailleau, Pascal,Beau, Jean-Marie
supporting information, p. 9991 - 9994 (2015/06/22)
The three-component Petasis borono-Mannich reaction starting with easily accessible N-protected α-amino aldehydes produces efficiently and diastereoselectively 1,2-trans-diamines with an enantiomeric excess of up to 98%.
Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase
Chan, Laval,Reddy, T. Jagadeeswar,Proulx, Mélanie,Das, Sanjoy K.,Pereira, Oswy,Wang, Wuyi,Siddiqui, Arshad,Yannopoulos, Constantin G.,Poisson, Carl,Turcotte, Nathalie,Drouin, Alexandre,Alaoui-Ismaili, M. Hicham,Bethell, Richard,Hamel, Martine,L'Heureux, Lucille,Bilimoria, Darius,Nguyen-Ba, Nghe
, p. 1283 - 1285 (2007/10/03)
The HCV NS5B RNA dependent RNA polymerase plays an essential role in viral replication. The discovery of a novel class of inhibitors based on an N,N-disubstituted phenylalanine scaffold and structure-activity relationships studies to improve potency are described.
Compounds and methods for the treatment or prevention of flavivirus infections
-
Page 19, (2010/02/05)
the present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating Flaviviridae viral infection.
