4785-04-0

Basic information

• Product Name: Guanylyl-(3,5)-cytidine
• Synonyms: 3-HgCl-furan;3-Chlor-mercuri-furan;[3']guanylic acid cytidin-5'-yl ester;[3']Guanylsaeure-cytidin-5'-ylester;cytidylyl-(5'->3')-guanosine;[3]furylmercury (1+),chloride;3-Chlormercurio-furan;[3]Furylquecksilber(1+),Chlorid;Mercury,chloro-3-furanyl
• CAS NO: 4785-04-0
• Molecular Formula: C₁₉H₂₅N₈O₁₂P
• Molecular Weight: 588.428
• Mol File: 4785-04-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 1057.6oC at 760 mmHg
• Flash Point: 593.4oC
• Density: 2.31g/cm3
• CAS DataBase Reference: Guanylyl-(3,5)-cytidine(CAS DataBase Reference)
• NIST Chemistry Reference: Guanylyl-(3,5)-cytidine(4785-04-0)
• EPA Substance Registry System: Guanylyl-(3,5)-cytidine(4785-04-0)

Safety Data

• Hazardous Substances Data: 4785-04-0(Hazardous Substances Data)

Upstream product

• 634-02-6 guanosine 2',3'-cyclic monophosphate 
• 65-46-3 CYTIDINE 

Relevant articles and documents

Synthesis of oligoribonucleotides with phosphonate-modified linkages

Solid phase synthesis of phosphonate-modified oligoribonucleotides using 2′-O-benzoyloxymethoxymethyl protected monomers is presented in both 3′→5′ and 5′→3′ directions. Hybridisation properties and enzymatic stability of oligoribonucleotides modified by regioisomeric 3′- and 5′-phosphonate linkages are evaluated. The introduction of the 5′-phosphonate units resulted in moderate destabilisation of the RNA/RNA duplexes (ΔTm -1.8 °C/mod.), whereas the introduction of the 3′-phosphonate units resulted in considerable destabilisation of the duplexes (ΔTm -5.7 °C/mod.). Molecular dynamics simulations have been used to explain this behaviour. Both types of phosphonate linkages exhibited remarkable resistance in the presence of ribonuclease A, phosphodiesterase I and phosphodiesterase II.

Synthetic reactions of ribonuclease T1.

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