478537-64-3

Basic information

• Product Name: 4-(2-carboxy-phenyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid
• Synonyms: 4-(2-carboxy-phenyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid
• CAS NO: 478537-64-3
• Molecular Weight: 259.262
• Mol File: 478537-64-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-carboxy-phenyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-carboxy-phenyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid(478537-64-3)
• EPA Substance Registry System: 4-(2-carboxy-phenyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid(478537-64-3)

Safety Data

• Hazardous Substances Data: 478537-64-3(Hazardous Substances Data)

Upstream product

• 17264-73-2 sodium o-bromobenzoate 
• 56741-51-6 3-(o-methoxycarbonylphenyl)pentane-2,4-dione 
• 52962-26-2 3-(o-carboxyphenyl)pentane-2,4-dione 
• 478288-10-7 ethyl 4-(o-carboxyphenyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate 
• 478288-12-9 ethyl 4-(o-methoxycarbonylphenyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate 

Downstream Products

• 478288-11-8 8-(o-carboxyphenyl)-3-ethyl-2,7,9-trimethyl-1,10-dihydro-11H-dipyrrin-1-one 
• 478288-09-4 3-ethyl-8-[(2-methoxycarbonyl)phenyl]-2,7,9-trimethyl-1,10-dihydro-11H-dipyrrin-1-one 

Relevant articles and documents

Atropisomerism in linear tetrapyrroles

Novel bilirubin and biliverdin congeners with propionic acids replaced by o-carboxyphenyl exhibit diastereomerism due to axial chirality about the carbon-carbon single bond linking the o-carboxyphenyl group to a pyrrole ring. Evidence for atropisomerism was found even in the monopyrrole precursor, ethyl 3,5-dimethyl-4-(o-carboxyphenyl)pyrrole-2-carboxylate. Like bilirubin, o-carboxyphenyl rubin 1a adopts an intramolecularly hydrogen-bonded ridge-tile conformation in nonpolar solvents. In solutions containing optically active amines or human serum albumin 1a exhibits intense bisignate exciton coupling-type induced circular dichroism for its long wavelength absorption near 400nm.