478548-21-9

Basic information

• Product Name: tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate
• Synonyms: tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate
• CAS NO: 478548-21-9
• Molecular Weight: 429.359
• Mol File: 478548-21-9.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate(478548-21-9)
• EPA Substance Registry System: tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate(478548-21-9)

Safety Data

• Hazardous Substances Data: 478548-21-9(Hazardous Substances Data)

Upstream product

• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 190579-73-8 2-benzyloxycarbonylamino-3-iodo-propionic acid tert-butyl ester 
• 59859-77-7 2-benzyloxycarbonylamino-3-hydroxy-propionic acid tert-butyl ester 
• 1053719-24-6 oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester 

Downstream Products

• 149560-64-5 (S)-5,5,5,5',5',5'-hexafluoroleucine 

Relevant articles and documents

ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS

The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the naturally occurring cyclic depsipeptide PF1022A. The invention also provides compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS

The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

A short and efficient synthesis of L-5,5,5,5',5',5'-hexafluoroleucine from N-Cbz-L-serine.

[reaction: see text] 5,5,5,5',5',5'-Hexafluoroleucine (6), a fluorous analogue of leucine, is of considerable interest as a building block in the design of fluorous proteins and peptides. We report a short and efficient synthesis of 6, which is obtained f