478555-55-4Relevant academic research and scientific papers
Aeruginoguanidines 98-A-98-C: Cytotoxic unusual peptides from the cyanobacterium Microcystis aeruginosa
Ishida, Keishi,Matsuda, Hisashi,Okita, Yuji,Murakami, Masahiro
, p. 7645 - 7652 (2002)
Aeruginoguanidines 98-A-98-C (1-3) were isolated from the cyanobacterium Microcystis aeruginosa (NIES-98). The structures of aeruginoguanidines 98-A-98-C (1-3) were determined by two-dimensional 1H-1H and 1H-13C NMR correlation experiments and confirmed by mass spectral analysis. The absolute stereochemistry of 1, consisting of Hphpa trisulfate (1-(4-hydroxy-3-hydroxymethyl)phenyl-1-hydroxy-2-propylamine 4′,3′,1-tri-O-sulfate), MpArg (Nα-methyl-Nω-prenylarginine) and MgArg ((Z)-Nα-methyl-Nω-geranylarginine), was determined by the NMR analyses of phenylglycine methyl ester (PGME) or Boc phenylglycine (BPG) derivatives of acid hydrolysates. These compounds showed moderate cytotoxicity against the P388 murine leukemia cells.
