2-methoxy-4,6-dimethylpyrimidine-5-carboxylic acid, also known as trimethoprim, is a dihydrofolate reductase inhibitor antibiotic that is primarily used to treat bacterial infections. It functions by inhibiting the activity of dihydrofolate reductase, an enzyme crucial for bacterial DNA and RNA synthesis, thereby disrupting nucleic acid production and leading to bacterial death.
4786-61-2
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Basic information
- Product Name: 2-methoxy-4,6-dimethylpyrimidine-5-carboxylic acid
- Synonyms: 2-methoxy-4,6-dimethylpyrimidine-5-carboxylic acid;2-Methoxy-4,6-dimethyl-5-pyrimidinecarboxylic acid;5-PyriMidinecarboxylicacid,2-Methoxy-4,6-diMethyl
- CAS NO:4786-61-2
- Molecular Formula: C8H10N2O3
- Molecular Weight: 182.1766
- EINECS: N/A
- Product Categories: N/A
- Mol File: 4786-61-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 367℃
- Flash Point: 176℃
- Appearance: /
- Density: 1.256
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- PKA: 2.86±0.39(Predicted)
- CAS DataBase Reference: 2-methoxy-4,6-dimethylpyrimidine-5-carboxylic acid(CAS DataBase Reference)
- NIST Chemistry Reference: 2-methoxy-4,6-dimethylpyrimidine-5-carboxylic acid(4786-61-2)
- EPA Substance Registry System: 2-methoxy-4,6-dimethylpyrimidine-5-carboxylic acid(4786-61-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 4786-61-2(Hazardous Substances Data)
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4786-61-2 Usage
Uses
Used in Pharmaceutical Industry:2-methoxy-4,6-dimethylpyrimidine-5-carboxylic acid is used as an antibiotic for treating various bacterial infections, such as urinary tract infections, respiratory infections, and traveler's diarrhea. Its mechanism of action involves inhibiting the enzyme dihydrofolate reductase, which is essential for nucleic acid synthesis in bacteria, ultimately resulting in bacterial death.
While generally well-tolerated, trimethoprim may cause side effects like nausea, vomiting, and skin rashes, and should be used under the guidance of a healthcare professional to ensure safe and effective treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 4786-61-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,8 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.Calculate Digit Verification of CAS Registry Number 4786-61:
(6*4)+(5*7)+(4*8)+(3*6)+(2*6)+(1*1)=122
122 % 10 = 2
So 4786-61-2 is a valid CAS Registry Number.
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2-methoxy-4,6-dimethylpyrimidine-5-carboxylic acid
