478613-35-3Relevant academic research and scientific papers
Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties
Palin, Ronald,Bom, Anton,Clark, John K.,Evans, Louise,Feilden, Helen,Houghton, Andrea K.,Jones, Philip S.,Montgomery, Brian,Weston, Mark A.,Wishart, Grant
, p. 1828 - 1847 (2008/02/03)
A series of 3-phenoxypropyl piperidine benzimidazol-2-one analogues have been discovered as novel NOP receptor agonists. Structure-activity relationships have been explored via N-3 substitution of the benzimidazol-2-one with a range of functionality. The
Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists
Palin, Ronald,Barn, David R.,Clark, John K.,Cottney, Jean E.,Cowley, Phillip M.,Crockatt, Marc,Evans, Louise,Feilden, Helen,Goodwin, Richard R.,Griekspoor, Frank,Grove, Simon J.A.,Houghton, Andrea K.,Jones, Philip S.,Morphy, Richard J.,Smith, Alasdair R.C.,Sundaram, Hardy,Vrolijk, David,Weston, Mark A.,Wishart, Grant,Wren, Paul
, p. 589 - 593 (2007/10/03)
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
