478798-40-2Relevant academic research and scientific papers
Carbanion stabilization by distal silyloxy groups. Origin of the high diastereoselectivity in the formation of quaternary centers with aryllead(IV) triacetate reagents
Konopelski, Joseph P.,Lin, Jinzhen,Wenzel, Philip J.,Deng, Hongbo,Elliott, Gregory I.,Gerstenberger, Brian S.
, p. 4121 - 4123 (2002)
(formula presented) Derivatives of methyl 5-hydroxy-2-oxo-1-cyclohexanecarboxylate react with aryllead(IV) reagents in high yield and with wide variation in diastereoselectivity. Ab initio calculations are consistent with a heretofore unrecognized attract
HISTONE METHYLTRANSFERASE INHIBITORS
-
Page/Page column 100, (2018/07/29)
The present disclosure provides certain angular tricyclic compounds that are histone methyltransi erases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinpathies (e.g., beta- thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
