478837-59-1

Basic information

• Product Name: 5-AMINO-3-BROMO (1H)INDAZOLE
• Synonyms: 3-BroMo-1H-indazol-5-ylaMine;5-AMINO-3-BROMO (1H)INDAZOLE;5-AMINO-3-BROMOINDAZOLE;3-bromo-1H-indazol-5-amine;1H-Indazol-5-aMine, 3-broMo-
• CAS NO: 478837-59-1
• Molecular Formula: C₇H₆BrN₃
• Molecular Weight: 212.05
• Product Categories: CHIRAL CHEMICALS
• Mol File: 478837-59-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 431.342 °C at 760 mmHg
• Flash Point: 214.668 °C
• Appearance: /
• Density: 1.867 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.8
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.34±0.40(Predicted)
• CAS DataBase Reference: 5-AMINO-3-BROMO (1H)INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3-BROMO (1H)INDAZOLE(478837-59-1)
• EPA Substance Registry System: 5-AMINO-3-BROMO (1H)INDAZOLE(478837-59-1)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 478837-59-1(Hazardous Substances Data)

Usage

Uses

3-Bromo-1H-indazol-5-amine acts as a reagent for the preparation of Polycyclic indazole derivatives that are ERK inhibitors and their use in the treatment and prevention of cancer, anilino quinazolines as antitumor agents.

InChI:InChI=1/C7H6BrN3/c8-7-5-3-4(9)1-2-6(5)10-11-7/h1-3H,9H2,(H,10,11)

Upstream product

• 5401-94-5 5-nitroindazole 
• 67400-25-3 3-bromo-5-nitro-1H-indazole 

Downstream Products

• 936361-35-2 3-(pyridin-4-yl)-1H-indazol-5-amine 
• 1356087-71-2 C₁₄H₁₀N₄ 
• 395099-48-6 3-(4-fluoro-phenyl)-1H-indazol-5-ylamine 
• 1175859-35-4 3-(2-fluorophenyl)-1H-indazol-5-amine 

Relevant articles and documents

INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

FUSED TETRAZOLES AS LRRK2 INHIBITORS

The present invention is directed to fused tetrazoles of formula (IA) which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.