478915-96-7Relevant academic research and scientific papers
Amino acid-based dithiazines: Synthesis and photofragmentation of their benzaldehyde adducts
Kurchan, Alexei N.,Kutateladze, Andrei G.
, p. 4129 - 4131 (2007/10/03)
(formula presented) α-Amino acids and GABA are functionalized with dithiazine rings via reaction with sodium hydrosulfide in aqueous formaldehyde. The resulting dithiazines are lithiated at -78°C and reacted with benzaldehyde furnishing amino acid-based 2,5-bis-substituted dithiazines. These adducts undergo externally sensitized photofragmentation with quantum efficiency comparable to that of the parent dithiane adducts, thus offering a novel approach to amino acid-based photolabile tethers.
