478945-06-1Relevant academic research and scientific papers
Stereoselective synthesis of amino-substituted apio dideoxynucleosides through a distant neighboring group effect
Choi, Won Jun,Ahn, Hee Sung,Kim, Hea Ok,Kim, Sanghee,Chun, Moon Woo,Jeong, Lak Shin
, p. 6241 - 6243 (2002)
Novel amino-substituted apio nucleoside (2R,4R)-LJ-45 as a potential anti-HBV agent was stereoselectively synthesized from the known oxazolidine 1 through a distant neighboring group effect. It is believed that this synthetic method using a chiral template, (-)-L-serine methyl ester can be generally applied to the synthesis of other chiral amino-substituted nucleosides.
