478968-83-1Relevant academic research and scientific papers
AMINOPYRIMIDINE COMPOUND
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Paragraph 1085; 1400-1401, (2020/04/10)
The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids.
Cottineau, Bertrand,Toto, Patrick,Marot, Christophe,Pipaud, Aline,Chenault, Jacques
, p. 2105 - 2108 (2007/10/03)
The synthesis and in vivo activities of a series of substituted pyrazole-4-carboxylic acids as hypoglycemic agents are described. Modelization of some potent compounds, comparatively to the metformine, presents certain analogies permitting to predict the design of some novel antidiabetic drugs.
