479035-92-2

Basic information

• Product Name: (-)-N⁴-benzoyl-1-[(1S,2S,4R)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-L-ribofuranosyl]-5-fluorocytosine
• Synonyms: (-)-N⁴-benzoyl-1-[(1S,2S,4R)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-L-ribofuranosyl]-5-fluorocytosine
• CAS NO: 479035-92-2
• Molecular Weight: 760.838
• Mol File: 479035-92-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-N⁴-benzoyl-1-[(1S,2S,4R)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-L-ribofuranosyl]-5-fluorocytosine(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-N⁴-benzoyl-1-[(1S,2S,4R)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-L-ribofuranosyl]-5-fluorocytosine(479035-92-2)
• EPA Substance Registry System: (-)-N⁴-benzoyl-1-[(1S,2S,4R)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-L-ribofuranosyl]-5-fluorocytosine(479035-92-2)

Safety Data

• Hazardous Substances Data: 479035-92-2(Hazardous Substances Data)

Upstream product

• 479035-91-1 (2R,4R/S)-4-acetylsulfanyl-5-tert-butyldiphenylsilyloxy-2-fluoropentanoic acid methyl ester 
• 479035-90-0 (2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester 
• 398133-33-0 (2S,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-2-phenylselenyl-γ-thiobutyrolactone 
• 398133-32-9 (2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone 
• 398133-29-4 (2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-butyrolactone 
• 34837-55-3 Phenylselenyl bromide 
• 10357-07-0 N-benzoyl-5-fluorocytosine 
• 398133-34-1 (1S/R,2S,4R)-1-O-aceyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-L-ribofuranoside 

Downstream Products

• 479035-95-5 (+)-N⁴-benzoyl-1-[(1S,4R)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2,3-didehydro-2-fluoro-4-thio-β-L-ribofuranosyl]-5-fluorocytosine 

Relevant articles and documents

Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2′,3′-didehydro-2′,3′-dideoxy-2 ′-fluoro-4′-thionucleosides

β-L-2′,3′-Didehydro-2′,3′-dideoxy-2 ′-fluoro-4′-thionucleosides β-L-2′-F-4′-S-d4Ns) have been synthesized and evaluated against HIV-1 in primary human lymphocytes. The key intermediate 8, which was prepared from 2,3-O-isopropylidene-L-glyceraldehyde 1 in