479036-13-0Relevant academic research and scientific papers
Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2′,3′-didehydro-2′,3′-dideoxy-2 ′-fluoro-4′-thionucleosides
Choo, Hyunah,Chong, Youhoon,Choi, Yongseok,Mathew, Judy,Schinazi, Raymond F.,Chu, Chung K.
, p. 389 - 398 (2007/10/03)
β-L-2′,3′-Didehydro-2′,3′-dideoxy-2 ′-fluoro-4′-thionucleosides β-L-2′-F-4′-S-d4Ns) have been synthesized and evaluated against HIV-1 in primary human lymphocytes. The key intermediate 8, which was prepared from 2,3-O-isopropylidene-L-glyceraldehyde 1 in
