479067-92-0Relevant academic research and scientific papers
Biosynthesis inspired Diels-Alder route to pyridines: synthesis of the 2,3-dithiazolylpyridine core of the thiopeptide antibiotics.
Moody, Christopher J,Hughes, Rachael A,Thompson, Stewart P,Alcaraz, Lilian
, p. 1760 - 1761 (2002)
Reaction of serine derived 1-alkoxy-2-azadienes with dehydroalanine derived dienophiles results in Diels-Alder reaction and aromatisation to give 2,3,6-trisubstituted pyridines, thereby establishing the viability of the proposed biosynthetic route to the
Total synthesis of the thiopeptide antibiotic amythiamicin D
Hughes, Rachael A.,Thompson, Stewart P.,Alcaraz, Lilian,Moody, Christopher J.
, p. 15644 - 15651 (2007/10/03)
The thiopeptide (or thiostrepton) antibiotics are a class of sulfur containing highly modified cyclic peptides with interesting biological properties, including reported activity against MRSA and malaria. Described herein is the total synthesis of the thi
