479077-02-6

Basic information

• Product Name: MMPIP HYDROCHLORIDE
• Synonyms: 6-(4-METHOXYPHENYL)-5-METHYL-3-(4-PYRIDINYL)-ISOXAZOLO[4,5-C]PYRIDIN-4(5H)-ONE HYDROCHLORIDE;MMPIP HYDROCHLORIDE;MMPIP;6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one
• CAS NO: 479077-02-6
• Molecular Formula: C19H15N3O3.HCl
• Molecular Weight: 333.34
• Product Categories: Glutamate
• Mol File: 479077-02-6.mol

Chemical Properties

• Boiling Point: 603.2±55.0 °C(Predicted)
• Appearance: white to off-white/
• Density: 1.292±0.06 g/cm3(Predicted)
• Storage Temp.: Desiccate at RT
• Solubility: DMSO: ≥10mg/mL
• PKA: 2.15±0.10(Predicted)
• CAS DataBase Reference: MMPIP HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: MMPIP HYDROCHLORIDE(479077-02-6)
• EPA Substance Registry System: MMPIP HYDROCHLORIDE(479077-02-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• WGK Germany: 3
• Hazardous Substances Data: 479077-02-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
MMPIP Hydrochloride is used as a research compound for studying the role of mGluR7 in various physiological and pathological processes. Its ability to block agonist-induced calcium mobilization makes it a valuable tool in understanding the receptor's function and potential therapeutic applications.
Used in Neurological Applications:
MMPIP Hydrochloride is used as a potential therapeutic agent for neurological disorders associated with the dysregulation of mGluR7, such as anxiety, depression, and chronic pain. By blocking the receptor, it may help alleviate symptoms and improve the quality of life for patients suffering from these conditions.
Used in Drug Development:
MMPIP Hydrochloride serves as a starting point for the development of new drugs targeting mGluR7. Its antagonistic properties can be further optimized and modified to create more potent and selective compounds with improved pharmacokinetic and pharmacodynamic profiles.
Used in Drug Delivery Systems:
To enhance the bioavailability and therapeutic outcomes of MMPIP Hydrochloride, various drug delivery systems can be employed. These systems, such as nanoparticles or liposomes, can improve the compound's solubility, stability, and targeted delivery to specific tissues or cells, potentially increasing its efficacy and reducing side effects.

Biological Activity

Potent allosteric mGlu 7 -selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC 50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC 50 = 15 nM), indicating inverse agonist activity.