479195-08-9

Upstream product

• 85068-33-3 3,5-bistrifluoromethylphenyl acetic acid 
• 479195-02-3 2-(3,5-bis-trifluoromethyl-phenyl)-hex-5-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide 
• 479195-00-1 2-(3,5-bis-trifluoromethyl-phenyl)-hex-5-enoic acid (4-oxo-1-phenyl-cyclohexyl)-amide 
• 479194-97-3 2-(3,5-bis-trifluoromethyl-phenyl)-hex-5-enoic acid 
• 877056-26-3 2-(3,5-bis-trifluoromethyl-phenyl)-hex-5-enoyl chloride 
• 479195-05-6 2-(3,5-bis-trifluoromethyl-phenyl)-5-hydroxy-pentanoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide 

Downstream Products

• 479195-10-3 3-(3,5-bis-trifluoromethyl-phenyl)-1-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-piperidin-2-one 
• 479195-14-7 3-(3,5-bis-trifluoromethyl-phenyl)-1-(4-oxo-1-phenyl-cyclohexyl)-piperidin-2-one 

Relevant academic research and scientific papers

Novel lactam NK1 antagonists with anti-emetic activity

A series of 4,4-disubstituted cyclohexylamine NK1 antagonists containing a lactam ring is described. The compounds are brain penetrant and activity is demonstrated in a ferret emesis model.