479195-27-2

Upstream product

• 479195-15-8 3-(3,5-bis-trifluoromethyl-phenyl)-1-(4-oxo-1-phenyl-cyclohexyl)-pyrrolidin-2-one 
• 176-69-2 2-oxa-8-azaspiro[4.5]decane 
• 374791-58-9 (RS)-N-(4-oxo-1-phenylcyclohexyl)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide 
• 479195-11-4 3-(3,5-bis-trifluoromethyl-phenyl)-1-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one 
• 479195-03-4 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide 
• 479195-09-0 2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide 
• 85068-33-3 3,5-bistrifluoromethylphenyl acetic acid 
• 479195-06-7 2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide 
• 334477-38-2 (RS)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid 
• 877056-25-2 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoyl chloride 

Relevant academic research and scientific papers

Novel lactam NK1 antagonists with anti-emetic activity

A series of 4,4-disubstituted cyclohexylamine NK1 antagonists containing a lactam ring is described. The compounds are brain penetrant and activity is demonstrated in a ferret emesis model.