479197-65-4Relevant academic research and scientific papers
Regio- and enantioselective alkylation of a N-protected pyrrolidin-3-one using Enders' chiral hydrazone method: A key step towards a new asymmetric total synthesis of (-)-quinocarcin and related analogues
Schneider, Uwe,Pannecoucke, Xavier,Quirion, Jean-Charles
, p. 1669 - 1672 (2002)
The synthesis of C-4-alkylated pyrrolidin-3-one 5 was achieved by regio- and diastereoselective alkylation of chiral hydrazone 8 with electrophile 7 followed by selective deprotection. Highly functionalised compound 5 is the first key intermediate in our approach towards a new asymmetric total synthesis of (-)-quinocarcin (1) and related structural analogues 2 and 3.
