479198-74-8

Basic information

• Product Name: Methylthiazol-2-ylcarbaMic acid tert-butyl ester
• Synonyms: Methylthiazol-2-ylcarbaMic acid tert-butyl ester
• CAS NO: 479198-74-8
• Molecular Formula: C₉H₁₄N₂O₂S
• Molecular Weight: 214.28466
• Mol File: 479198-74-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 268.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.192±0.06 g/cm3(Predicted)
• PKA: 3.68±0.10(Predicted)
• CAS DataBase Reference: Methylthiazol-2-ylcarbaMic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methylthiazol-2-ylcarbaMic acid tert-butyl ester(479198-74-8)
• EPA Substance Registry System: Methylthiazol-2-ylcarbaMic acid tert-butyl ester(479198-74-8)

Safety Data

• Hazardous Substances Data: 479198-74-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 170961-15-6 tert-butyl 1,3-thiazole-2-yl-carbamate 
• 74-88-4 methyl iodide 

Downstream Products

• 1314095-64-1 tert-butyl 5-bromothiazol-2-yl(methyl)carbamate 
• 543729-93-7 [5-((R)-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-hydroxy-methyl)-thiazol-2-yl]-methyl-carbamic acid tert-butyl ester 
• 543729-95-9 {5-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-thiazol-2-yl}-methyl-carbamic acid tert-butyl ester 

Relevant articles and documents

INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF

The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.

A short and highly stereoselective synthesis of α-(2-aminothiazolyl)-C-nucleosides

A short route to novel α-(2-aminothiazolyl)-C-nucleosides has been developed. The key step was the high diastereoselective reduction of the hemiacetal intermediates using L-Selectride, which afforded the corresponding R-diols in quantitative yields. These diols were converted, after C4-C1 ring closure and protecting groups cleavage, to their corresponding free α-C-nucleosides.