479234-83-8

Basic information

• Product Name: 1-METHYL-1,4,5,10-TETRAHYDROBENZO[B]PYRAZOLO[3,4-E][1,4]DIAZEPINE
• Synonyms: 1-METHYL-1,4,5,10-TETRAHYDROBENZO[B]PYRAZOLO[3,4-E][1,4]DIAZEPINE;1-methyl-4,5-dihydro-2H-pyrazolo[4,3-c][1,5]benzodiazepine;Pyrazolo[3,4-b][1,5]benzodiazepine, 1,4,5,10-tetrahydro-1-methyl-
• CAS NO: 479234-83-8
• Molecular Formula: C₁₁H₁₂N₄
• Molecular Weight: 200.23978
• Mol File: 479234-83-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 416.2±44.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 6.79±0.20(Predicted)
• CAS DataBase Reference: 1-METHYL-1,4,5,10-TETRAHYDROBENZO[B]PYRAZOLO[3,4-E][1,4]DIAZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1,4,5,10-TETRAHYDROBENZO[B]PYRAZOLO[3,4-E][1,4]DIAZEPINE(479234-83-8)
• EPA Substance Registry System: 1-METHYL-1,4,5,10-TETRAHYDROBENZO[B]PYRAZOLO[3,4-E][1,4]DIAZEPINE(479234-83-8)

Safety Data

• Hazardous Substances Data: 479234-83-8(Hazardous Substances Data)

Usage

General Description

1-Methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine, also known as Ro10-5824, is a chemical compound with potential pharmaceutical applications. It is a member of the diazepine family and is structurally related to benzodiazepines. 1-METHYL-1,4,5,10-TETRAHYDROBENZO[B]PYRAZOLO[3,4-E][1,4]DIAZEPINE is a psychoactive drug with sedative and anxiolytic properties, making it a potential candidate for the treatment of anxiety and related disorders. Its chemical structure and pharmacological effects make it an interesting candidate for further research and development in the field of central nervous system therapeutics. However, its exact mechanisms of action and potential side effects need to be further studied to fully understand its potential in clinical applications.

Upstream product

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• 50-00-0 formaldehyd 
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Downstream Products

• 744200-39-3 3-Methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraazabenzo[f]azulene-9-carbonyl)-benzonitrile 
• 479234-62-3 2-methyl-4-(1-methyl-1,3a,4,5,10,10a-hexahydrobenzo[b]-pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzonitrile 
• 1209963-38-1 5-[2-chloro-4-(3-methyl-1H-pyrazol-1-yl)benzoyl]-1-methyl-1,4,5,10-tetrahydro pyrazolo[3,4-b][1,5]benzodiazepine 

Relevant articles and documents

SALTS AND CRYSTALS

This invention relates to solid forms of 1-methyl-1,4,5,10-tetrahydropyrazolo[3,4-b][1,5]benzodiazepine freebase possessing desirable pharmacokinetic properties, such as low hygroscopicity and improved thermal stability. These solid forms include a crystalline form of 1-methyl-1,4,5,10-tetrahydropyrazolo[3,4-b][1,5]benzodiazepine 5 freebase and phosphate and L-tartrate salts of 1-methyl-1,4,5,10-tetrahydropyrazolo[3,4-b][1,5]benzodiazepine freebase. Pharmaceutical compositions, medicaments and kits comprising these solid forms are also described. Also provided are methods of using these forms to treat various diseases, conditions and disorders.

Conformationally rigid derivatives of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin-1a receptors

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The Formation of Seven-Membered Heterocycles under Mild Pictet-Spengler Conditions: A Route to Pyrazolo[3,4]benzodiazepines

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