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479244-15-0

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479244-15-0 Usage

General Description

2-Propenamide, 3-(3,4-dihydroxyphenyl)-N-propyl-, (2E)- (9CI) is a chemical compound with the molecular formula C12H15NO2. It is a derivative of 3-(3,4-dihydroxyphenyl)prop-2-enamide and is classified as an (E)-2-Propenamide compound. This chemical is used in various industrial and pharmaceutical applications due to its potential as a therapeutic agent for diseases and conditions like cancer, inflammation, and neurodegenerative disorders. It also has antioxidant and antimicrobial properties, making it potentially useful in a range of medical and cosmetic products. Additionally, this compound has been studied for its potential role in the development of new materials and drug delivery systems, making it a widely researched chemical with diverse applications.

Check Digit Verification of cas no

The CAS Registry Mumber 479244-15-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,9,2,4 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 479244-15:
(8*4)+(7*7)+(6*9)+(5*2)+(4*4)+(3*4)+(2*1)+(1*5)=180
180 % 10 = 0
So 479244-15-0 is a valid CAS Registry Number.

479244-15-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(3,4-dihydroxyphenyl)-N-propylprop-2-enamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:479244-15-0 SDS

479244-15-0Downstream Products

479244-15-0Relevant articles and documents

In Vivo Cardioprotective Effects and Pharmacokinetic Profile of N-Propyl Caffeamide Against Ischemia Reperfusion Injury

Cheng, Yuan-Yuan,Luo, Dan,Xia, Zhengyuan,Tse, Hung-Fat,Li, Xuechen,Rong, Jianhui

, p. 145 - 156 (2017)

Caffeic acid derivatives constitute a class of potent anti-inflammatory and cardioprotective drug candidates. We recently synthesized a new caffeic acid derivative N-propyl caffeamide (PCA). Our pilot experiments demonstrated that PCA enhanced the survival of rat cardiomyocyte H9c2 cells against oxygen glucose deprivation and reoxygenation challenge in a concentration-dependent manner. Interestingly, PCA exhibited better cardioprotective potential than caffeic acid phenethyl ester and propyl caffeate. Thus, we hypothesized that PCA could protect heart against ischemia reperfusion (I/R) injury in mice. We first determined the stability and pharmacokinetic profile of PCA in male Sprague–Dawley rats by ultra-performance liquid chromatography coupled with UV and MS/MS detections. The stability of PCA in rat plasma was defined by the half-life of 31.39, 7.19 and 1.37?h in rat plasma at 25, 37 and 60?°C, respectively. To study the pharmacokinetic profiles, PCA was injected into male SD rats at the dose of 15?mg/kg via intravenous bolus administration. PCA showed the elimination half-life of approximate 235?min in rats. We subsequently evaluated the cardioprotective potential of PCA in mice model of myocardial infarction. Our results demonstrated that PCA effectively reduced infarct size and release of myocardial enzymes (e.g., CK, CK-MB and LDH). Biochemical analyses suggested that PCA increased the activities of antioxidant enzymes (e.g., CAT and SOD) while attenuated lipid peroxidation. Moreover, PCA profoundly reduced the number of apoptotic cells in infarcted myocardium. Consistently, PCA increased the expression level of anti-apoptotic protein Bcl2 whereas suppressed the expression of pro-apoptotic protein Bax in cardiac tissues. Collectively, PCA appears to be a novel bioavailable and stable pharmacological treatment for myocardial infarction.

Lipase-Catalyzed Solvent-Free Amidation of Phenolic Acids

Kaushik, Parshant,Shakil, Najam Akhtar,Kumar, Jitendra,Singh, Braj Bhushan

supporting information, p. 579 - 587 (2015/10/29)

A series of N-alkyl-substituted amides, based on various phenolic acids, have been synthesized by the condensation of equimolar amounts of phenolic acids with different alkyl amines in the presence of Candida antarctica lipase at 60-90 °C in 16-20 h. The reactions were carried out in a solvent-free system without the use of any activating agents. All the products were obtained in appreciable amounts and the yields for different compounds varied between 75.6% and 83.5%. The synthesized compounds were characterized using spectroscopy techniques, namely infrared and NMR (1H and 13C). GRAPHICAL ABSTRACT.

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