4793-29-7Relevant academic research and scientific papers
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases
Zak?auskas, Audrius,?apkauskait?, Edita,Jezep?ikas, Linas,Linkuvien?, Vaida,Ki?onait?, Migl?,Smirnov, Alexey,Manakova, Elena,Gra?ulis, Saulius,Matulis, Daumantas
, p. 61 - 78 (2018)
Rational design of compounds that would bind specific pockets of the target proteins is a difficult task in drug design. The 12 isoforms of catalytically active human carbonic anhydrases (CAs) have highly similar active sites that make it difficult to des
