47934-36-1

Basic information

• Product Name: C,C-dideuterio-methylamine
• Synonyms: C,C-dideuterio-methylamine
• CAS NO: 47934-36-1
• Molecular Weight: 33.0415
• Mol File: 47934-36-1.mol

Chemical Properties

• CAS DataBase Reference: C,C-dideuterio-methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: C,C-dideuterio-methylamine(47934-36-1)
• EPA Substance Registry System: C,C-dideuterio-methylamine(47934-36-1)

Safety Data

• Hazardous Substances Data: 47934-36-1(Hazardous Substances Data)

Upstream product

• 79-16-3 N-methyl-acetamide 
• 82134-80-3 N-methyl-N-acetyldimethylphosphoramidate 
• 13294-10-5 diethyl N-acetyl-N-methylphosphoramidate 
• 1113-68-4 N-methyldiacetamide 
• 2290-65-5 trimethylsilyl isothiocyanate 

Relevant articles and documents

β-deuterium Isotope Effects on Amine Basicity, Inductive and Stereochemical

Secondary β deuterium isotope effects on acidity constants of ammonium ions are measured using a remarkably precise NMR titration method. Deuteration is found to increase the basicity of methylamine, dimethylamine, benzylamine, and N,N-dimethylaniline. The effect is attributed to a lowered zero-point energy of a CH bond adjacent to an amine nitrogen. The method permits a determination of the stereochemical dependence of the isotope effect in a locked piperidine, and it is found that deuteration is more effective when antiperiplanar to a lone pair. The values are consistent with a cos2 dependence on dihedral angle, with no detectable angle-independent inductive effect. Copyright

Phosphoric-Carboxylic Imides. 2. Solvolytic Cleavage of the Nitrogen-Carbonyl and Nitrogen-Phosphoryl Bonds

The neutral and acid-catalyzed solvolysis (hydrolysis and alcoholysis) of mixed phosphoric-carboxylic imides (1), X2P(O)-NR-C(O)R'(X = EtO, MeO, CH2O, Et; R = H, Me; R'= Me, Ph) has been studied and compared with the solvolytic behavior of parent phosphoric and carboxylic amides and symmetrical imides.The neutral cleavage of the P-N bond is believed to involve an oxyphosphorane intermediate.The ionization of 1 follows the amide acidity function, with half-protonation at the carbonyl oxygen atom occuring at ca. 70percent D2SO4.The remarkable stability of the P-N bond in acidic solutions, together with the susceptibility of the N-C(O)solvolysis toward acid catalysis, is consistent with the exclusion of the N-protonation of 1 and is in accordance with carbonyl oxygen protonation and the significant electron-withdrawing effect of the N-phosphinyl substituent.The hydration parameter treatment was applied to the acid-catalyzed N-C(O) hydrolysis of 1d (1, X = EtO; R = R'= Me), and the results are compared with those obtained for the acid-catalyzed hydrolysis of N-methylacetamide.The acidic solvolysis of 1, with respect to both the P(O)-N and N-C(O) cleavage, lies between the extremes characterized by the respective parent amides and symmetrical imides.