479347-86-9 Usage
Biological Activity
nbqx disodium salt is a potent, highly selective and competitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa) receptors (ampars). the ampar is one type of ionotropic glutamate receptors, well known to be involved in various neurological disorders such as alzheimer disease, schizophrenia, and epilepsy, by mediating long-term potentiation, excitotoxicity, or both. inhibition of ampars with nbqx shows neuroprotective and anticonvulsant activity.1. fukushima k, tabata y, imaizumi y, et al. characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. journal of biomolecular screening, 2014, 19(8): 1174-1184.2. chen w, li ys, gao j, et al. ampa receptor antagonist nbqx decreased seizures by normalization of perineuronal nets. plos one, 2016, 11(11): e0166672.
Check Digit Verification of cas no
The CAS Registry Mumber 479347-86-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,9,3,4 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 479347-86:
(8*4)+(7*7)+(6*9)+(5*3)+(4*4)+(3*7)+(2*8)+(1*6)=209
209 % 10 = 9
So 479347-86-9 is a valid CAS Registry Number.
